您的当前位置:首页 > 特色产品
Antibody Internalization Kit


Antibody-drug conjugates (ADCs), which have become a new targeted therapy against cancer, consist of an antibody linked to a cytotoxic drug. The ADCs bind selectively to the target cancer cells via the monoclonal antibody portion. Internalization of the ADCs releases the drug to do its damage. This achieves target-specific killing of tumor cells while minizing systemic toxicity of the cytotoxic drug.


AlpVHHs offers a new generation of nano-secondary antibody-drug conjugates linked to MMAE, MMAF, DM1, or Duocarmycin, etc for antibody internalization detection.  Using Nano-secondary antibody-drug conjugates (nano-2°ADC) in a cell-based cytotoxic assay is a quick and economical alternative to pre-screening monoclonal antibodies as ADC candidates against tumor cells. Nano-2°ADCs are highly specific with minimally toxicity to cells in the absence of primary antibodies. No obvious change of the primary antibody activity in the presence of the unconjugated secondary antibody.


Nano-secondary antibody-Drug conjugates
Code Description Applications Size Price
023-101-101 Anti-Human IgG, AlpSdAbs® VHH(VcMMAE ×4) Internalization Test 100ug 5000
023-101-111 Anti-Human IgG, AlpSdAbs® VHH(VcMMAE ×8) Internalization Test 100ug 5000
023-101-102 Anti-Human IgG, AlpSdAbs® VHH(VcMMAF ×4) Internalization Test 100ug 5000
023-101-112 Anti-Human IgG, AlpSdAbs® VHH(VcMMAF ×8) Internalization Test 100ug 5000
023-101-103 Anti-Human IgG, AlpSdAbs® VHH(VcDXD ×4) Internalization Test 100ug 5000
023-101-113 Anti-Human IgG, AlpSdAbs® VHH(VcDXD ×8) Internalization Test 100ug 5000
023-101-104 Anti-Human IgG, AlpSdAbs® VHH(VcPBD ×4) Internalization Test 100ug 5000
023-101-114 Anti-Human IgG, AlpSdAbs® VHH(VcPBD ×8) Internalization Test 100ug 5000
001-101-101 Anti-Mouse IgG, AlpSdAbs® VHH(VcMMAE ×4) Internalization Test 100ug 5000
001-101-111 Anti-Mouse IgG, AlpSdAbs® VHH(VcMMAE ×8) Internalization Test 100ug 5000
001-101-102 Anti-Mouse IgG, AlpSdAbs® VHH(VcMMAF ×4) Internalization Test 100ug 5000
001-101-112 Anti-Mouse IgG, AlpSdAbs® VHH(VcMMAF ×8) Internalization Test 100ug 5000
001-101-103 Anti-Mouse IgG, AlpSdAbs® VHH(VcDXD ×4) Internalization Test 100ug 5000
001-101-113 Anti-Mouse IgG, AlpSdAbs® VHH(VcDXD ×8) Internalization Test 100ug 5000
001-101-104 Anti-Mouse IgG, AlpSdAbs® VHH(VcPBD ×4) Internalization Test 100ug 5000
001-101-114 Anti-Mouse IgG, AlpSdAbs® VHH(VcPBD ×8) Internalization Test 100ug 5000


Nano-pH-sensitive probe
Code Description Applications Size Price
023-101-011 Anti-Human IgG, AlpSdAbs® VHH(pH-Green 500) Internalization Test 100ug 5000
023-101-012 Anti-Human IgG, AlpSdAbs® VHH(pH-Red 600) Internalization Test 100ug 5000
001-101-011 Anti-Mouse IgG, AlpSdAbs® VHH(pH-Green 500) Internalization Test 100ug 5000
001-101-012 Anti-Mouse IgG, AlpSdAbs® VHH(pH-Red 600) Internalization Test 100ug 5000


Nano-DT
Code Description Applications Size Price
023-101-020 Anti-Human IgG, AlpSdAbs® VHH(DT) Internalization Test 100ug 2500
001-101-020 Anti-Mouse IgG, AlpSdAbs® VHH(DT) Internalization Test 100ug 2500