Technical service
Antibody development
Nanoantibody development
Development of GPCR nanobodies
CAR Molecular Development
Development of anti small molecule antibodies
Hongbei Shuyi in car antibody development
Development of anti idiotypic antibodies
Shark antibody development
Rabbit monoclonal antibody development
Sheep monoclonal antibody development
Platform
Yeast Display Technology Platform
Phage Display Technology Platform
Protein expression platform
Protein expression platform
Protein expression platform
Technical service
Nanoantibody expression
Nano antibody labeling platform
Affinity detection
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Contact
Telephone：+86 4008677715
Address：Floor 5, unit 2, building 10, No. 319, Qingpi Avenue, Wenjiang District, Chengdu
Email：service@alpvhhs.com
Nanoantibody development

CAR Molecular Development

CAR-T（Chimeric Antigen Receptor T-cell Therapy）免疫治疗通过CAR识别肿瘤细胞，并释放细胞因子，发挥抗肿瘤作用。CAR主要由胞外结构域、跨膜结构域和胞内结构域组成。胞外结构域中的抗体片段（scFv或者VHH）可决定抗原的特异性和亲和力，跨膜结构域可影响CAR在细胞表面表达，胞内结构域中共刺激域与信号转导结构域则起到信号活化转导使T细胞发挥杀伤力的作用。其中，特异性好、亲和力高的抗体制备工艺，将有助于筛选到副作用小、杀伤作用强的CAR序列。


针对CAR后选分子，临界点生物建立了三大抗体开发平台（噬菌体抗体库、杂交瘤、酵母展示、），可获得多样化的结合序列，满足scFv与VHH发现的需求。通过对候选分子的分析，可制备多表位或多特异CAR分子。



服务流程

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服务优势

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CAR结构域VHH抗体研发案例

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